Peer-reviewed veterinary case report
Mesalazine treatment effects on stomach inflammation in dogs with IBD
By Rychlik, A et al.·Published in Polish journal of veterinary sciences·2009·University of Warmia and Mazury in Olsztyn·View original on PubMed →
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Original publication title: Macroscopic and histopathological examination of the gastric mucosa in dogs with inflammatory bowel disease (IBD) treated with mesalazine.
- Species:
- dog
Plain-English summary
Eighteen dogs with inflammatory bowel disease (IBD) were treated with mesalazine, a medication that helps reduce inflammation. These dogs showed signs of chronic gastritis, which is inflammation of the stomach lining, and many had abnormal changes in their intestinal tissue. After six weeks of treatment, the dogs' stomach linings showed improvement, with less inflammation observed in their tissue samples. This suggests that mesalazine can be effective in treating gastric issues related to IBD in dogs.
People also search for: dog inflammatory bowel disease treatment · mesalazine for dogs · dog chronic gastritis symptoms
Abstract
The objective of this study was to carry out a macroscopic and histopathological examination of the gastric mucosa in dogs with inflammatory bowel disease and to evaluate the effect of mesalazine therapy on histopathological changes in the gastric mucosa. The treatment was performed on 18 dogs with histopathologically confirmed inflammation of the duodenum and the jejunum. The animals were administered mesalazine at 12.5 mg/kg b.w. bid over a six-week period. The dogs investigated were diagnosed with chronic catarrhal gastritis with intense lymphocytic/plasmocytic infiltration. In 83% of the dogs, intestinal metaplasia had been noted in bioptates before examination. The results of macroscopic and microscopic examinations revealed that the applied treatment had a positive effect on gastric mucosal morphology. Cellular infiltration of the gastric mucosa was significantly inhibited, most probably, due to the anti-inflammatory effect of mesalazine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19645352/