Peer-reviewed veterinary case report
MRI features linked to brain meningioma types in 112 dogs
By Sturges, B K et al.·Published in Journal of veterinary internal medicine·2008·Department of Surgical and Radiological Sciences, United States·View original on PubMed →
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Original publication title: Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs.
- Species:
- dog
Plain-English summary
A group of 112 dogs diagnosed with brain tumors called meningiomas were studied to understand their types and how they appear on MRI scans. Most of these tumors were found in Golden Retrievers and Boxers, with 56% being benign and 43% atypical. Unfortunately, the MRI features did not help predict the tumor's type or severity, meaning that a tissue sample is still needed for an accurate diagnosis. This is important because the atypical tumors in dogs may respond less effectively to treatment compared to similar tumors in humans.
People also search for: dog brain tumor symptoms · Golden Retriever meningioma treatment · Boxer brain tumor MRI results
Abstract
BACKGROUND: Intracranial meningiomas are the most common primary brain tumors in dogs. Classification of meningiomas by tumor grade and subtype has not been reported, and the value of magnetic resonance imaging (MRI) characteristics for predicting tumor subtype and grade has not been investigated. HYPOTHESIS: Canine intracranial meningiomas are a heterogenous group of tumors with differing histological subtypes and grades. Prediction of histopathological classification is possible based on MRI characteristics. ANIMALS: One hundred and twelve dogs with a histological diagnosis of intracranial meningioma. METHODS: Retrospective observational study. RESULTS: Meningiomas were overrepresented in the Golden Retriever and Boxer breeds with no sex predilection. The incidence of specific tumor grades was 56% benign (Grade I), 43% atypical (Grade II), and 1% malignant (Grade III). Grade I histological subtypes included meningothelial (43%), transitional (40%), microcystic (8%), psammomatous (6%), and angiomatous (3%). No statistically significant (P < .05) associations were found among tumor subtype or grade and any of the MRI features studied. CONCLUSIONS AND CLINICAL IMPORTANCE: Meningiomas in dogs differ from their counterparts in humans mainly in their higher incidence of atypical (Grade II) tumors observed. MRI characteristics do not allow for prediction of meningioma subtype or grade, emphasizing the necessity of histopathology for antemortem diagnosis. The higher incidence of atypical tumors in dogs may contribute to the poorer therapeutic response in dogs with meningiomas as compared with the response in humans with meningiomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18466258/