Peer-reviewed veterinary case report
Magnetic resonance imaging and pathological features of a mixed glioma in a dog: case report
- Journal:
- Arquivo Brasileiro de Medicina Veterinária e Zootecnia
- Authors:
- T.M. Granato et al.
- Species:
- dog
Plain-English summary
A 12-year-old male boxer dog was examined after passing away, and a special brain scan called an MRI was done before his death. The MRI showed an unusual growth in the brain that was hard to define, with some swelling and changes in nearby areas. When the brain was looked at closely after death, it revealed a soft mass with bleeding, made up of two different types of abnormal cells. The diagnosis was a mixed glioma, which is a type of brain tumor, based on both the MRI results and the detailed examination of the brain tissue.
Abstract
ABSTRACT The aim of this report was to describe the magnetic resonance imaging (MRI) and pathological features of a canine mixed glioma. A 12-year-old boxer male dog was presented for necropsy along with data from an MRI evaluation conducted ante-mortem. The images were examined and showed a poorly demarcated prosencephalic lesion, hyperintense on T2W images, hypointense on T1W images and heterogeneously hyperintense on T2W FLAIR images. There was mild nonuniform contrast enhancement, apparent midline shift, moderate perilesional edema and marked distortion of the adjacent lateral ventricle. The brain was evaluated macroscopically, microscopically and immunohistochemically. Grossly, there was a poorly demarcated soft mass, with areas of hemorrhage, within the left parietal and temporal lobes. Histologically, there was a densely cellular mass composed of two geographically distinct populations of neoplastic cells. The first population was composed of small and round cells organized in a honeycomb pattern. The second population constituted of intermingled streams and bundles of neoplastic cells that were strongly immunolabeled for glial fibrillary acidic protein (GFAP). The diagnosis of a mixed glioma was based on MRI findings, and mainly on histological and immunohistochemical findings.
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Search related cases →Original publication: https://doi.org/10.1590/1678-4162-10474