Peer-reviewed veterinary case report
Genetic risk factors for brain inflammation in young Irish greyhounds
By Shiel, R E et al.·Published in Tissue antigens·2014·University College Dublin·View original on PubMed →
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Original publication title: Major histocompatibility complex class II alleles and haplotypes associated with non-suppurative meningoencephalitis in greyhounds.
- Species:
- dog
Plain-English summary
A young greyhound in Ireland was diagnosed with non-suppurative meningoencephalitis, a serious brain inflammation condition. Researchers found that certain genetic markers, known as DLA class II haplotypes, were linked to this disease in affected dogs. Specifically, two haplotypes were significantly associated with the condition, indicating a potential genetic risk factor. This suggests that some greyhounds may be more prone to developing this neuroinflammatory disorder due to their genetics. Understanding these associations could help in identifying at-risk dogs and developing better treatments in the future.
People also search for: greyhound meningoencephalitis symptoms · young greyhound brain inflammation · genetic risk factors in dogs
Abstract
Non-suppurative meningoencephalitis is a breed-restricted canine neuroinflammatory disorder affecting young greyhounds in Ireland. A genetic risk factor is suspected because of the development of disease in multiple siblings and an inability to identify a causative infectious agent. The aim of this study was to examine potential associations between dog leucocyte antigen (DLA) class II haplotype and the presence of the disease. DLA three locus haplotypes were determined in 31 dogs with non-suppurative meningoencephalitis and in 115 healthy control dogs using sequence-based typing (SBT) methods. All dogs were unrelated at the parental level. Two haplotypes (DRB1*01802/DQA1*00101/DQB1*00802 and DRB1*01501/DQA1*00601/DQB1*02201) were significantly (P = 0.0099 and 0.037) associated with the presence of meningoencephalitis, with odds ratios (95% confidence interval) of 5.531 (1.168-26.19) and 3.736 (1.446-9.652), respectively. These results confirm that there is an association between DLA class II haplotype and greyhound meningoencephalitis, suggesting an immunogenetic risk factor for the development of the disease. Greyhound meningoencephalitis may be a suitable model for human neuroinflammatory diseases with an immunogenetic component.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24851745/