Peer-reviewed veterinary case report
Malakoplakia bladder inflammation in 4 puppies explained
By Davis, Katelin L et al.·Published in Veterinary pathology·2021·311308Purdue University, United States·View original on PubMed →
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Original publication title: Malakoplakia in the Urinary Bladder of 4 Puppies.
- Species:
- dog
Plain-English summary
Four puppies were diagnosed with malakoplakia, a rare inflammatory condition affecting the urinary bladder, which can be linked to infections. The puppies showed signs of bladder inflammation, and tests confirmed bacterial infections in two of them. Microscopic examinations revealed abnormal macrophages, which are immune cells that can indicate inflammation. While the puppies received treatment for the infections, the specific outcomes for their recovery were not detailed. If your puppy has urinary issues, it's important to consult your vet for appropriate testing and treatment.
People also search for: puppy urinary bladder infection · malakoplakia in dogs · puppy bladder inflammation treatment
Abstract
Malakoplakia in humans most often affects the urinary bladder and is characterized by inflammation with von Hansemann-type macrophages, with or without Michaelis-Gutmann bodies, and is frequently associated withinfection. We describe the microscopic features of malakoplakia in the urinary bladder of 4 puppies. In all cases, the lamina propria of the urinary bladder was markedly expanded by sheets of large, round to polygonal macrophages with intracytoplasmic, periodic acid-Schiff-positive granules and granular inclusions, and rare Prussian blue-positive inclusions. Macrophages were positive for CD18 and Iba1. In 2 cases, Michaelis-Gutmann bodies were detected with hematoxylin and eosin stain and were best demonstrated with von Kossa stain.infection was confirmed in 2 cases with bacterial culture or polymerase chain reaction (PCR) and sequencing of the bacterial 16S ribosomal RNA gene. Transmission electron microscopy of one case demonstrated macrophages with abundant lysosomes, phagolysosomes, and rod-shaped bacteria. Microscopic features were similar to human cases of malakoplakia. In dogs, the light microscopic characteristics of malakoplakia closely resemble granular cell tumors and histiocytic ulcerative colitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33888013/