Peer-reviewed veterinary case report
Malignant testicular tumors with skin spread in two dogs
By Kudo, Tomoo et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2019·PATHO LABO, Japan·View original on PubMed →
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Original publication title: Malignant Leydig cell tumor in dogs: two cases and a review of the literature.
- Species:
- dog
Plain-English summary
A 5-year-old male dog presented with a rapidly growing mass in the corner of his mouth, which turned out to be a malignant Leydig cell tumor (MLCT), a rare type of testicular cancer. Another dog had multiple skin masses on his neck, back, and hind leg, also diagnosed with MLCT. Both dogs showed signs of tumor spread to the skin, and their tumors were aggressive, with high cell division rates. Unfortunately, the prognosis for malignant Leydig cell tumors can be poor, and treatment options may include surgery and monitoring for further spread.
People also search for: dog mouth tumor · malignant testicular cancer in dogs · skin lumps on dog neck · treatment for dog testicular cancer
Abstract
Malignant Leydig cell tumor (MLCT) is a rare testicular tumor in dogs. We report herein 2 dogs with MLCT and cutaneous metastasis. Grossly, marked enlargement and distortion of the involved testes were noted; on cut surface, the parenchyma was completely replaced by neoplastic tissue. In addition, these tumors had extensive necrosis and hemorrhage. Case 1 had a rapidly growing cutaneous mass in the left angle of the mouth; the lesion was well-circumscribed and had an indistinct lobular pattern. Case 2 had multiple cutaneous masses in the dorsal neck region, the thoracic back region, and the right hindlimb. Microscopically, the tumor lobules were composed of oval-to-polyhedral cells with eosinophilic cytoplasm and resembled testicular tumors. By immunohistochemistry, the neoplastic cells in both the testicular and cutaneous tumors were positive for inhibin-alpha and melan A. The mitotic counts of the primary tumors from cases 1 and 2 were 21 and 11 per 10 high-power fields, respectively. Based on these findings, the cases were diagnosed as MLCT with cutaneous metastasis. Ki-67 expression in the neoplastic cells of the 2 cases was higher than in benign Leydig cell tumors. Our findings may be helpful for the diagnosis of canine MLCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31248354/