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Peer-reviewed veterinary case report

Malignant melanoma in the foot of a horse.

Journal:
Journal of the American Veterinary Medical Association
Year:
1990
Authors:
Honnas, C M et al.
Affiliation:
Veterinary Medical Teaching Hospital · United States
Species:
horse

Plain-English summary

A 24-year-old horse had a malignant melanoma, which is a type of skin cancer, on its right front foot. After surgery to remove the tumor, the doctors found that they hadn't completely taken it out, so they treated the area with a special implant that included a cancer-fighting drug and other materials to help the healing process. The horse's foot healed well, and for 26 months, it showed no signs of the disease returning. Unfortunately, when the cancer came back, it was found to be widespread in the foot, and the decision was made to euthanize the horse.

Abstract

A 24-year-old horse had a malignant melanoma of the right forefoot. Because surgical excision of the melanoma was incomplete, as determined by histologic examination of the excised tissue margins, the tumor margins were injected with a matrix therapeutic implant containing cis-diamminedichloroplatinum, epinephrine, and purified bovine collagen matrix. The foot healed and the horse remained clinically free of disease for 26 months before recurrence of malignant melanoma. Surgical exploration of the digit revealed extensive involvement of the foot, and the horse was euthanatized.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/2211329/