Peer-reviewed veterinary case report
Malignant nerve sheath tumor from adrenal gland in a dog
By Ichikawa, Mika et al.·Published in The Journal of veterinary medical science·2018·Japan Animal Referral Medical Center, Japan·View original on PubMed →
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Original publication title: Malignant peripheral nerve sheath tumor originating from the adrenal gland in a dog.
- Species:
- dog
Plain-English summary
A dog was found to have a large abdominal mass that was identified as a malignant peripheral nerve sheath tumor (MPNST) originating from the adrenal gland. Unfortunately, the tumor had spread to other parts of the body, leading to multiple metastatic lesions. Despite efforts to treat the condition, the dog's health continued to decline, and the difficult decision was made to euthanize the dog due to the severity of the disease. This case highlights a rare occurrence of MPNST starting in the adrenal gland of a dog.
People also search for: dog abdominal mass treatment · malignant tumor in dog · adrenal gland tumor in dogs · dog euthanasia decision
Abstract
A large abdominal mass was found in a dog. Histopathologically, the surface of the mass was covered with compressed adrenal gland tissue. The neoplastic cells showed typical features of malignant peripheral nerve sheath tumor (MPNST), including Antoni type A and type B pattern, and nuclear palisading. Immunohistochemically, these cells were positive for S100 protein, nerve growth factor receptor, nestin and claudin-1. The dog was euthanized because of the developing multiple metastatic lesions. The metastatic cells showed quite similar histopathological and immunohistochemical features as those in the original tumor. Although MPNST can develop at many body sites, this is the first report of MPNST originating from the adrenal gland in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30175755/