Peer-reviewed veterinary case report
Malignant rhabdoid tumour in the orbit of a horse.
- Journal:
- Journal of comparative pathology
- Year:
- 1999
- Authors:
- Hong, C B et al.
- Affiliation:
- Department of Veterinary Science · United States
- Species:
- horse
Plain-English summary
A 2-year-old Thoroughbred filly was found to have a malignant rhabdoid tumor, which is a very aggressive type of cancer, in the area around her eye. This tumor had spread extensively, affecting not just the eye and surrounding tissues, but also the lymph nodes in her head and neck, as well as her salivary glands. The tumor cells were unusual in shape and had specific features that were identified under a microscope. Unfortunately, the aggressive nature of this tumor suggests a serious prognosis.
Abstract
A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments. The neoplastic cells were immunoreactive to vimentin and cytokeratin antisera, but were negative for desmin and actin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/10405312/