Peer-reviewed veterinary case report
Malignant transformation and subsequent leptomeningeal carcinomatosis of a gastric polyp in a dog.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2024
- Authors:
- Didehvar, Dillon S et al.
- Affiliation:
- Department of Clinical Science & Advanced Medicine · United States
- Species:
- dog
Abstract
Progressive carcinogenesis of a gastric polyp with transformation to gastric adenocarcinoma and subsequent development of leptomeningeal carcinomatosis is described in an adult male Scottish terrier. Presenting clinical signs consisted of vomiting with intermittent hematemesis. Surgical biopsies over the course of 14 months documented the progression from gastric polyp to minimally invasive gastric carcinoma to invasive gastric adenocarcinoma, a pathogenesis not previously documented in veterinary oncology. The patient ultimately developed neurologic pathology and was euthanized, and necropsy evaluation identified widespread carcinomatosis with accompanying leptomeningeal metastasis. As in humans, gastric polyps in dogs rarely have malignant potential.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38587203/