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Peer-reviewed veterinary case report

Managing cat hyperthyroidism and preventing oxidative stress

By Candellone, Alessia et al.·Published in Antioxidants·2021·Department of Veterinary Sciences, School of Agriculture and Veterinary Medicine, University of Turin, Largo Braccini, 2, 10095 Grugliasco, Italy, Italy·View original on Crossref

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Original publication title: Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?

Species:
cat

Plain-English summary

A cat with hyperthyroidism, which causes excessive thyroid hormone production, may show symptoms like increased thirst, weight loss, and hyperactivity. The standard treatment is a medication called methimazole, but it can have side effects and may worsen oxidative stress in the body. Research in humans suggests that adding antioxidants to the diet can help reduce these side effects. This review highlights the potential benefits of using dietary antioxidants alongside methimazole in cats to improve their overall health and manage hyperthyroidism more effectively.

People also search for: cat hyperthyroidism treatment · methimazole side effects in cats · antioxidants for cats with hyperthyroidism

Abstract

Feline hyperthyroidism is a clinical syndrome related to an excessive production of thyroid hormones, and it is considered as a spontaneous animal model for human thyrotoxicosis. Many shared features between the feline and the human disease have been identified so far, including pathogenesis, clinical signs, and treatment options. Although methimazole is considered the first-choice drug in both species, several side effects have been described. Furthermore, methimazole could interfere with the oxidative status, already perturbated by the disease. It has been reported in humans that dietary management, mainly through antioxidant supplementation, could mitigate this oxidative burden. The purpose of the review is to describe current therapeutic options in the course of feline hyperthyroidism and to summarize the state of the art relationship between dietary antioxidants administration and the reduction of methimazole side-effects in humans to support the use of this approach also in cats.

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Original publication on Crossref: https://doi.org/10.3390/antiox10091496