Peer-reviewed veterinary case report
Unexpected problems with genetically altered mice - how to manage them
By Pritt, Stacy et al.·Published in Lab animal·2006·Covance Research Products, United States·View original on PubMed →
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Original publication title: Management of unanticipated outcomes in transgenic mouse facilities.
Plain-English summary
This study looks at how unexpected health issues can arise in genetically modified mice used for research, which can create challenges for both regulations and animal care. The authors explain a system they developed at Harvard Medical School that uses special cards to keep track of these mice, helping to spot and manage any unexpected health problems early on. This approach aims to improve the care of these animals and ensure compliance with regulations. The outcome of using this tracking system is not specified, but it is designed to enhance the management of these situations.
Abstract
Experimental manipulations of rodents may result in unexpected adverse phenotypes that present problems from both regulatory and animal care-veterinary perspectives. The authors discuss the implications of unanticipated outcomes and describe a cage card-based tracking system used at the Harvard Medical School for the early detection and handling of unanticipated phenotypes in genetically altered rodents.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16582897/