Peer-reviewed veterinary case report
Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals.
- Journal:
- Biomaterials science
- Year:
- 2019
- Authors:
- Adhikari, Aniruddha et al.
- Affiliation:
- Department of Chemical · India
- Species:
- rodent
Abstract
Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized MnOnanoparticles; C-MnONPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-MnONPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31566646/