Peer-reviewed veterinary case report
Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2015
- Authors:
- Hamaguchi, Shogo et al.
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- rodent
Abstract
Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca(2+). The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26318676/