Peer-reviewed veterinary case report
Maropitant given before morphine cuts vomiting in cats
By Martin-Flores, Manuel et al.·Published in Journal of feline medicine and surgery·2017·1 Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine reduces the incidence of emesis in cats.
- Species:
- cat
Plain-English summary
A group of healthy female cats was given a medication called maropitant about 2-2.5 hours before receiving morphine and dexmedetomidine for sedation. The cats that received maropitant had significantly less retching and vomiting compared to those that did not receive the medication. While maropitant helped reduce these symptoms, it did not affect other signs of nausea, like drooling or lip licking. This suggests that maropitant could be helpful for preventing vomiting in cats needing sedation, but further adjustments to the dosing schedule may be needed for better results.
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Abstract
Objectives The main goal of this study was to test the antiemetic effects of maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine in cats. Methods Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n = 39) or no treatment (control; n = 44), 2-2.5 h prior to morphine 0.1 mg/kg and dexmedetomidine 20 µg/kg intramuscularly. The incidence of sialorrhea, lip licking, retching and vomiting were recorded after morphine/dexmedetomidine injection. Results There were no differences between groups in terms of age or weight. The treated group received a mean ± SD dose of maropitant of 2.9 ± 0.6 mg/kg. The incidence of sialorrhea and lip licking was no different between groups. The incidence of retching (control 36% vs maropitant 13%; P = 0.012) and emesis (control 32% vs maropitant 13%; P = 0.03) was significantly reduced in cats treated with maropitant. Conclusions and relevance Maropitant 8 mg (total dose) administered orally 2-2.5 h prior to morphine and dexmedetomidine significantly reduced, but did not eliminate, the incidences of retching and vomiting. Maropitant did not decrease the occurrence of sialorrhea and lip licking, signs that may be indicative of nausea. Maropitant might be useful for morning administration to prevent emesis in outpatient cats requiring sedation or anesthesia; however, dose regimens or interval of administration might require improvement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27538868/