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Peer-reviewed veterinary case report

Mast cell and plasma cell collision tumor in the spleen of a dog.

Journal:
Veterinary clinical pathology
Year:
2018
Authors:
Pallatto, Valarie A & Bechtold, Molly A
Affiliation:
ANTECH Diagnostics · United States
Species:
dog

Abstract

A 9-year-old spayed female English Mastiff was referred for outpatient ultrasound due to a 3-week history of weight loss, vomiting, and decreased appetite. Abdominal ultrasound showed multiple splenic masses of varying sizes and serum chemistry panel showed hyperglobulinemia. Cytologic examination of fine-needle aspirates of the splenic masses indicated a mast cell and plasma cell collision tumor. Results of serum and urine protein electrophoresis and immunofixation indicated the plasma cell neoplasia was producing IgA immunoglobulins.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/29902336/