Peer-reviewed veterinary case report
Mast cells found in nerve tissue of dog with mastocytosis
By Dines, K C et al.·Published in Journal of the peripheral nervous system : JPNS·1999·Department of Pathology, United States·View original on PubMed →
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Original publication title: Mast cell-associated Renaut bodies in the peroneal nerve of a dog with a history of mastocytosis.
- Species:
- dog
Plain-English summary
A dog with generalized weakness and nerve problems was found to have multiple Renaut bodies, which are abnormal structures in the nerve, during a biopsy of the common peroneal nerve. This dog also had a history of skin issues related to mast cell tumors and hypothyroidism. The examination revealed an unusual presence of mast cells near these Renaut bodies, suggesting a possible link between the two. The findings indicate that mast cells might play a role in the formation of these nerve abnormalities. Treatment details were not specified, but understanding this connection could help in managing similar cases in the future.
People also search for: dog nerve problems · mast cell tumors in dogs · Renaut bodies in dogs · dog weakness treatment · hypothyroidism in dogs
Abstract
Multiple Renaut bodies were identified by light microscopy in the biopsied common peroneal nerve of a dog with generalized neuropathy, hypothyroidism and a history of cutaneous mastocytosis. In addition, numerous granulated cells were associated with most of the Renaut bodies. Electron microscopic examination confirmed these to be mast cells, both central and peripheral to Renaut bodies, a phenomenon never previously reported. Endoneurial fibrosis, myelinated fiber loss, as well as evidence of axonal degeneration, demyelination and remyelination were observed. 'Vacuolation' of endoneurial fibroblasts was also present. The location of these Renaut bodies in the common peroneal nerve, and the absence of any documented or expected nerve compression, implicates other etiological factors. These observations are the first to report an association between mast cells and Renaut bodies. It is possible that mast cells, at least in this case, are involved in the formation of Renaut bodies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10197062/