Peer-reviewed veterinary case report
Mast cells linked to parvovirus gut infection in dogs with crypt
By Woldemeskel, M W et al.·Published in Veterinary pathology·2013·University of Georgia, United States·View original on PubMed →
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Original publication title: Mast cells in Canine parvovirus-2-associated enteritis with crypt abscess.
- Species:
- dog
Plain-English summary
A group of dogs with severe diarrhea and vomiting caused by Canine parvovirus (CPV-2) was studied to see if there were more mast cells (a type of immune cell) in their intestines compared to healthy dogs. The dogs with CPV-2 had a significantly higher number of mast cells than the control group, suggesting that these cells might play a role in the immune response to this virus. While the study didn't directly test treatments, understanding the role of mast cells could help in developing better therapies for dogs suffering from CPV-2 enteritis in the future.
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Abstract
The role of mast cells (MCs) in allergic reactions and parasitic infections is well established. Their involvement in host immune response against bacterial and viral infections is reported. In this study, investigation is made to determine if MCs are associated with Canine parvovirus-2 (CPV-2)-induced enteritis with crypt abscess (ECA). Mast cell count (MCC) was made on toluidine blue-stained intestinal sections from a total of 34 dogs. These included 16 dogs exhibiting ECA positive for CPV-2 and negative for Canine distemper virus and Canine coronavirus by immunohistochemistry and fluorescent antibody test, 12 dogs with inflammatory bowel disease (IBD), and 6 non-ECA/non-IBD (control) dogs. The average total MCC per high-power field in ECA (40.8 ± 2.2) and IBD (24.7 ± 2.1) was significantly higher (P < .05) than in the control (3.4 ± 0.6). Although not significant (P > .05), MCC was also higher in ECA than in IBD. The present study for the first time has documented significantly increased MCs in CPV-2-associated ECA as was previously reported for IBD, showing that MCs may also play an important role in CPV-2-associated ECA. Further studies involving more CPV-infected dogs are recommended to substantiate the findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23558973/