Peer-reviewed veterinary case report
Matrix metalloproteinase levels in West Highland terriers with lung
By Määttä, Merita et al.·Published in Journal of veterinary internal medicine·2021·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Matrix metalloproteinase-2, -7, and -9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases.
- Species:
- dog
Plain-English summary
A group of West Highland White Terriers (WHWTs) with idiopathic pulmonary fibrosis (CIPF), a serious lung disease, showed higher levels of certain proteins in their blood and lung fluid compared to healthy dogs and those with other lung issues. Specifically, the levels of pro-MMP-7 in their blood and pro-MMP-2 and pro-MMP-9 in their lung fluid were significantly elevated. These findings suggest that measuring these proteins could help diagnose CIPF in dogs, but they may not provide information on how the disease will progress. Treatment options were not detailed in the study, so it's important to consult your veterinarian for the best care plan.
People also search for: West Highland White Terrier lung disease · dog coughing treatment · idiopathic pulmonary fibrosis in dogs
Abstract
BACKGROUND: Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung disease that mainly affects West Highland white terriers (WHWTs) and is characterized by excessive deposition of extracellular matrix (ECM) in the lung. Matrix metalloproteinases (MMPs) participate in remodeling of ECM. OBJECTIVES: To compare metalloproteinase-2, -7 and -9 activities in blood or bronchoalveolar lavage fluid (BALF) samples or both of CIPF WHWTs with healthy WHWTs, healthy dogs of other breeds, and dogs with other lung diseases and determine if these MMPs could be used as diagnostic and prognostic markers for CIPF. ANIMALS: Forty-four CIPF WHWTs, 24 dogs with chronic bronchitis (CB), 17 with eosinophilic bronchopneumopathy (EBP), 10 with bacterial pneumonia, 39 healthy WHWTs, and 35 healthy dogs of other breeds. METHODS: Cross-sectional observational study. Pro-MMP and active MMP activities were analyzed by zymography. RESULTS: In serum, significantly higher (P < .01) pro-MMP-7 activities were observed in CIPF WHWTs compared to healthy dogs of other breeds, dogs with CB and dogs with EBP. In BALF of CIPF WHWTs, both pro-MMP-9 and pro-MMP-2 activities were significantly higher (P < .01) compared to healthy WHWTs, but these differences were not detected in plasma. The CIPF WHWTs had significantly higher (P < .05) activities of pro-MMP-9 compared to dogs with CB and of pro-MMP-2 compared to dogs with CB and EBP. No statistically significant prognostic factors were observed in CIPF WHWTs. CONCLUSIONS AND CLINICAL RELEVANCE: Serum MMP-7 and BALF MMP-2 and -9 potentially may be useful diagnostic markers but not prognostic markers for CIPF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33274549/