Peer-reviewed veterinary case report
MMP-9 enzyme found in spinal fluid of dogs with sudden disk injury
By Levine, Jonathan M et al.·Published in American journal of veterinary research·2006·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease.
- Species:
- dog
Plain-English summary
A group of 35 dogs with sudden back problems caused by intervertebral disk disease (IVDD) were tested for a protein called MMP-9 in their blood and spinal fluid. The study found that dogs showing signs of paralysis were more likely to have MMP-9 in their spinal fluid, especially if their symptoms had started less than 24 hours before. However, the presence of this protein didn't affect how long the dogs needed to stay in the hospital. Overall, the findings suggest that MMP-9 could be an important marker for early spinal cord injury in dogs.
People also search for: dog back problems IVDD · dog paralysis treatment · MMP-9 in dogs
Abstract
OBJECTIVE: To detect matrix metalloproteinase (MMP)-9 in serum and CSF and determine relationships between MMP activity and severity of disease, duration of clinical signs, and duration of hospitalization in dogs with acute intervertebral disk disease (IVDD). ANIMALS: 35 dogs with acute IVDD and 8 clinically normal control dogs. PROCEDURE: CSF and serum were collected from affected and control dogs. Zymography was used to detect MMP-9. RESULTS: Activity of MMP-9 in CSF was detected in 6 of 35 dogs with IVDD; activity was significantly more common in dogs with duration of signs < 24 hours. Paraplegic dogs were more likely to have MMP-9 activity in the CSF than non-paraplegic dogs. No significant difference in hospitalization time was detected in dogs with IVDD between those with and without activity of MMP-9 in the CSF. Serum MMP-9 was detected more frequently in dogs with IVDD than in control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Data were consistent with results of experimental rodent spinal cord injury studies that indicate that MMP-9 is expressed early during secondary injury.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16454634/