Peer-reviewed veterinary case report
Matrix metalloproteinase levels in joint fluid of dogs
By Salinardi, B J et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2006·Department of Clinical Science, United States·View original on PubMed →
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Original publication title: Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and synovial fluid of osteoarthritic dogs.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis (OA) showed changes in certain proteins in their joint fluid compared to healthy dogs. Specifically, the level of matrix metalloproteinase-1 (MMP-1) was higher in the joint fluid of dogs with OA, while the level of tissue inhibitor of metalloproteinase-2 (TIMP-2) was lower. These findings suggest that measuring these proteins could help in understanding and potentially diagnosing OA in dogs earlier. While the study didn't focus on treatment outcomes, knowing these protein levels can assist veterinarians in managing OA more effectively.
People also search for: dog osteoarthritis symptoms · how to treat dog arthritis · dog joint pain management
Abstract
To better understand the mechanisms responsible for the pathological processes of osteoarthritis (OA) and to potentially identify a profile of changes that could be predictive of early OA, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the synovial fluid and serum of normal and osteoarthritic dogs were examined. The concentration of MMP-1 in the synovial fluid of osteoarthritic dogs (0.62 +/- 0.16), as measured by densitometry, was significantly higher than that found in control dogs (0.42 +/- 0.19) (P = 0.03). The concentration of MMP-1 in the serum of osteoarthritic dogs (0.74 +/- 0.16) was significantly less than that found in control dogs (0.87 +/- 0.08) (P = 0.05). The concentration of TIMP-2 in the synovial fluid of osteoarthritic dogs (46.2 +/- 21.9 ng/ml) was significantly less than that of control dogs (122.0 +/- 66.5 ng/ml) (P = 0.009). The concentration of TIMP-2 in the serum of osteoarthritic dogs (116.2 +/- 43.1 ng/ml) was not significantly different than that of control dogs (95.1 +/- 94.4 ng/ml) (P = 0.554). In addition, a phospho-tyrosine immunoprecipitation and mass spectrometry were used to isolate and identify interferon-alpha in canine synovial fluid.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16594544/