Peer-reviewed veterinary case report
Intestinal lining leakiness measured in dogs
By Kobayashi, Saku et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Measurement of intestinal mucosal permeability in dogs with lymphocytic-plasmacytic enteritis.
- Species:
- dog
Plain-English summary
A group of 29 dogs with lymphocytic-plasmacytic enteritis (a type of inflammatory bowel disease) had their intestinal health assessed by measuring sugar levels in their urine. The results showed that these dogs had significantly higher levels of certain sugars compared to healthy dogs, indicating a problem with their intestinal barrier. This test could help veterinarians evaluate the extent of intestinal damage in dogs with this condition. While the study didn't focus on treatment outcomes, understanding intestinal permeability may guide future care for dogs suffering from this type of enteritis.
People also search for: dog inflammatory bowel disease symptoms · dog intestinal permeability test · treatment for dog lymphocytic-plasmacytic enteritis
Abstract
Lymphocytic-plasmacytic enteritis (LPE) is a type of canine inflammatory bowel disease (IBD). One of its most probable causes is a defect in the mucosal permeability barrier. In the present study, intestinal permeability in LPE dogs was examinated to evaluate its clinical value. Twenty-nine dogs with LPE diagnosed by clinical and histological examinations were included in this study. Intestinal permeability was evaluated by measuring the ratio of the concentrations of two sugars (lactulose (L) and rhamnose (R)) with different molecular weights in urine samples after oral administration of a solution containing them. Biopsy specimens of duodenum were evaluated according to histological criteria. The urinary L:R ratio in the 29 LPE dogs (1.68 +/- 1.17, mean +/- SD) was significantly higher than that in the 10 healthy control dogs (0.75 +/- 0.38, P<0.01). In the LPE dogs, a weak correlation was observed between the histopathological grading score of the duodenum and the urinary L:R ratio (r=0.408, P<0.05). The urinary L:R ratio in the 20 dogs showing hypoalbuminemia (< 2.5 g/dl) was significantly higher than that in the 9 dogs with normal serum albumin levels > 2.5 g/dl (P<0.01). In conclusion, permeability of the intestinal mucosa as determined by the urinary L:R ratio could be a useful laboratory parameter for evaluating intestinal damage in LPE dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17675807/