Peer-reviewed veterinary case report
Gentamicin levels in dogs after eye injection for glaucoma treatment
By Rankin, Amy J et al.·Published in Veterinary ophthalmology·2016·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma.
- Species:
- dog
Plain-English summary
A group of 24 dogs with chronic glaucoma received an injection of gentamicin directly into their eyes to help lower eye pressure. After the treatment, blood tests showed that gentamicin was absorbed into their bloodstream, with a success rate of 86.4% in reducing eye pressure after one month. This means that most dogs experienced relief from their glaucoma symptoms following the procedure. The treatment appears to be effective for managing this painful condition in dogs.
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Abstract
OBJECTIVE: To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure. ANIMALS: Twenty-four client-owned dogs with chronic, end-stage glaucoma. PROCEDURES: Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25-40 mg of gentamicin (mean ± SD dose 2.57 ± 1.65 mg/kg and range 0.61-7.50 mg/kg) and 1 mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry. RESULTS: The total plasma concentration of gentamicin ranged from 0.21 to 9.71 μg/mL (mean ± SD 2.15 ± 2.03). The mean gentamicin CMAX was 2.29 μg/mL at 2.54 h with a terminal half-life of 9.8 h. The success rate of the chemical ablation procedure was 86.4% (19/22 eyes) in dogs that had at least 1 month of follow-up. CONCLUSIONS: Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25688853/