Peer-reviewed veterinary case report
Measurement of pOin a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor.
- Journal:
- Advances in experimental medicine and biology
- Year:
- 2017
- Authors:
- Hou, H et al.
- Affiliation:
- Department of Radiology · United States
- Species:
- rabbit
Abstract
The objective of this work was to establish a novel and robust technology, based on electron paramagnetic resonance (EPR) oximetry, as a practical tool for measurement of tumor oxygen. Previously, we have reported on the development of oxygen-sensing paramagnetic crystals (LiNc-BuO) encapsulated in a biocompatible polymer, called OxyChip. In this report we present our recent data on the use of OxyChip for pOmeasurements in the tumor of a pre-clinical, large-animal rabbit model. The results establish that OxyChip is capable of noninvasive and repeated measurement of pOin a large animal model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28685460/