Peer-reviewed veterinary case report
Measuring salivary adiponectin levels in healthy dogs
By Tvarijonaviciute, Asta et al.·Published in Veterinary clinical pathology·2014·Departament de Medicina i Cirurgia Animals, Spain·View original on PubMed →
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Original publication title: Measurement of salivary adiponectin concentrations in dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs had their saliva tested for a protein called adiponectin, which can help understand their health better. The study found that after a tooth-cleaning procedure, the dogs' salivary adiponectin levels increased within 24 hours, likely due to inflammation or changes in their gums. However, by two weeks later, those levels dropped below what they were before the cleaning. This suggests that while tooth cleaning might temporarily raise certain health markers, the effects can change over time.
People also search for: dog tooth cleaning effects · dog saliva health markers · why is my dog's saliva different after cleaning
Abstract
BACKGROUND: Measurement of salivary adiponectin could improve understanding of this adipokine's physiology, and its role in various clinical conditions. OBJECTIVES: The purpose of the study was to evaluate the utility of a human adiponectin ELISA kit for measurement of salivary adiponectin in dogs, to compare serum and salivary adiponectin concentrations in a healthy dog population, and to evaluate possible effects of tooth-cleaning on serum and salivary adiponectin concentrations in dogs. METHODS: For analytical validation, precision, accuracy, and lower limit of quantification of the assay were determined with saliva samples. In addition, adiponectin concentrations were quantified in serum and saliva samples from 24 healthy dogs, and from 7 dogs with mild gingivitis before and after a tooth-cleaning procedure. RESULTS: The validation assays for salivary adiponectin had all coefficients of variation <15%, and recovery ranged from 85% to 120%. In the linearity test, interference was observed when measuring adiponectin in saliva, but this was solved by diluting samples 1:4. In healthy dogs, salivary and serum adiponectin concentrations were positively correlated (r = .650; P = .009). After the tooth-cleaning procedure, salivary adiponectin concentration increased on day 0 (P = .004), but by day 14, concentrations were less than prior to the procedure (P = .041). CONCLUSIONS: The human adiponectin ELISA kit can be used for precise and accurate salivary adiponectin measurement in dogs. Salivary adiponectin increased 24 hours after tooth-cleaning, possibly due to acute inflammation or adiponectin leakage from the blood after gingival trauma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25040360/