Peer-reviewed veterinary case report
Urine test for blood clot marker in dogs with bloat (GDV)
By Baltzer, Wendy I et al.·Published in American journal of veterinary research·2006·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus.
- Species:
- dog
Plain-English summary
A group of dogs with a serious condition called gastric dilatation-volvulus (GDV) had their urine tested to measure a specific substance (11-dehydro-thromboxane B2) before and after surgery. The results showed that dogs with GDV had much higher levels of this substance in their urine compared to healthy dogs, both when they were admitted to the hospital and after their stomachs were surgically corrected. Additionally, dogs that had higher levels of this substance after surgery were more likely to experience complications. This suggests that monitoring this urine marker could help predict recovery issues in dogs with GDV.
People also search for: dog GDV symptoms · dog surgery complications · urine test for dog health
Abstract
OBJECTIVE: To measure 11-dehydro-thromboxane B2 (11-dTXB2) in urine of healthy control dogs, dogs undergoing ovariohysterectomy, and dogs with gastric dilatation-volvulus (GDV) and assess the relationship between urinary 11-dTXB2 concentrations in dogs with GDV and postoperative outcomes. SAMPLE POPULATION: Urine samples from 15 nonsurgical control dogs, 12 surgical control dogs, and 32 dogs with GVD. PROCEDURE: Urine samples were obtained from healthy pet dogs (ie, nonsurgical control dogs), dogs undergoing ovariohysterectomy at anesthetic induction and 1 hour following surgery (ie, surgical control dogs), and dogs with GDV at hospital admission and 1 hour following surgical derotation of the stomach (ie, GDV dogs). Urinary 11-dTXB2 concentrations were determined with an ELISA and normalized to urinary creatinine (Cr) concentrations by calculation of the 11-dTXB2 -to-Cr ratio. Differences in median 11-dTXB2 -to-Cr ratios among dogs and before and after surgery were analyzed. RESULTS: Urinary 11-dTXB2-to-Cr ratios did not differ between nonsurgical control dogs and surgical control dogs before or after surgery. Urinary 11-dTXB2-to-Cr ratios were significantly higher in GDV dogs at the time of hospital admission and 1 hour after surgery, compared with those of nonsurgical control dogs. Postoperative urine samples from GDV dogs had significantly higher 11-dTXB2-to-Cr ratios than postoperative urine samples from surgical control dogs. Median urinary 11-dTXB2-to-Cr ratios increased significantly in GDV dogs that developed postoperative complications. CONCLUSIONS AND CLINICAL RELEVANCE: Urinary 11-dTXB2 concentration is increased in GDV dogs at the time of hospital admission and after surgical derotation of the stomach, compared with that of healthy dogs. An increased urinary 11-dTXB2-to-Cr ratio following surgery is associated with an increased incidence of postoperative complications in dogs with GDV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16426215/