Peer-reviewed veterinary case report
Canine eye inflammation after fluid sampling and carprofen effects
By Pinard, Chantale L et al.·Published in Veterinary ophthalmology·2011·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis.
- Species:
- dog
Plain-English summary
A group of beagles underwent a procedure called anterior chamber paracentesis (ACP) to relieve eye pressure, which led to inflammation in their eyes. After the procedure, levels of a substance called prostaglandin E(2) (PGE(2)), which indicates inflammation, increased significantly. When some of the dogs were given carprofen, a common anti-inflammatory medication, their PGE(2) levels were lower compared to those that did not receive the treatment. This suggests that carprofen may help reduce inflammation in the eyes after such procedures.
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Abstract
OBJECTIVES: Phase I: To evaluate levels of prostaglandin E(2) (PGE(2) ), nitrites and nitrates (NO(x) ), tumor necrosis factor-alpha (TNF-α) and expression of inducible cyclo-oxygenase (COX-2), nitric oxide synthase (NOS-2), and matrix metalloproteinases (MMP-3 and -9) in canine aqueous humor following repeated anterior chamber paracenteses (ACP). Phase II: to evaluate the effect of carprofen on PGE(2) , NO(x) , and TNF-α in canine aqueous humor following ACP. ANIMALS STUDIED: Four beagles in phase I and 8 beagles in phase II. PROCEDURES: Phase I: ACP was performed at time (T) 0, 4 and 8 h. Phase II: A randomized, placebo-controlled cross-over design with four dogs per group where carprofen was given 4.4 mg/kg/day on day (D) 1, 2 and 3. ACP was performed at T0 and T1.5 on D3. Statistical analysis was performed with repeated measures anova and post hoc Tukey-Kramer multiple-comparison procedure. In phase II, TNF-α level was analyzed with a Wilcoxon signed-rank test. RESULTS: Phase I: PGE(2) significantly increased (P < 0.0001) to plateau at T4. NO(X) was decreased at T4 (P < 0.06), but increased at T8 (P < 0.0001). COX-2 showed detectable expression only at T8. TNF-α, NOS-2, MMP-3 and -9 were undetectable at all time points. Phase II: At T1.5, PGE(2) was significantly elevated in both groups but was lower in the carprofen group (P = 0.037). NO(x) and TNF-α did not statistically increase in either group. CONCLUSIONS: Following ACP, significant increases in PGE(2) levels confirmed inflammation characterized by a rise of COX-2. The NO(x) pathway took longer to induce as compared with PGE(2) . Carprofen decreased PGE(2) levels and could help control intraocular inflammation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21929606/