Peer-reviewed veterinary case report
Plasma endothelin levels in healthy cats and cats with heart disease
By Prosek, Robert et al.·Published in Journal of veterinary internal medicine·2004·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Measurements of plasma endothelin immunoreactivity in healthy cats and cats with cardiomyopathy.
- Species:
- cat
Plain-English summary
A study measured a substance called endothelin-1 in healthy cats and those with heart disease, specifically cardiomyopathy. It found that cats with heart disease had higher levels of endothelin-1 in their blood compared to healthy cats, which could indicate more severe heart issues. The research included 12 healthy cats and 28 cats with different types of cardiomyopathy, showing that those with heart failure had the highest levels of this substance. This information could help veterinarians assess heart health in cats and guide treatment decisions.
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Abstract
Plasma concentrations of endothelin-1 (ET-1), the most potent endogenous pressor substance discovered to date, are abnormally high in humans with congestive heart failure (CHF), and they correlate with the degree of functional impairment. We sought first to validate a human sandwich ELISA kit that targets that portion of the amino acid sequence that is identical in cats. The assay demonstrated linearity (R2 = .9968) and parallelism (P = .5339), recovery of spiked human ET-1 in cat plasma averaged 98.7%, and intraassay precision had a coefficient of variation <10%. We subsequently determined ET-1 immunoreactivity in healthy cats and in cats with myocardial disease with and without CHF, systemic thromboembolism (STE), or both. Plasma ET-1 immunoreactivity was measured in 12 healthy cats and in 28 cats with primary myocardial disease, including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), or restrictive or unclassified cardiomyopathy (RCM and UCM), respectively. Plasma ET mean (95% CI) concentrations were 0.777 (0.6536-0.924) fmol/mL in the control cats, 1.427 (0.922-2.209) fmol/mL in 12 cats with cardiomyopathy (HCM = 11, RCM/UCM = 1) but without CHF or evidence of STE, and 2.360 (1.666-3.343) fmol/mL in 16 cats with cardiomyopathy (HCM = 8, RCM/UCM = 7, DCM = 1) and CHF (n = 15) or STE (n = 4). Plasma immunoreactivity of ET-1 was significantly higher in cats with myocardial disease without CHF/STE versus normal cats (P < .05) and in cats with myocardial disease with CHF/STE versus normal cats (P < .001).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15638265/