Mechanism of pulmonary plague biphasic syndrome: inhibition or activation of NF-κB signaling pathway.

Abstract

Pneumonic plague is a fatal respiratory disease caused by. Time-course transcriptome analysis on the mechanism of pneumonic plague biphasic syndrome is lacking in the literature.This study documented the disease course through bacterial load, histopathology, cytokine levels and flow cytometry. RNA-sequencing technology was used to investigate the global transcriptome profile of lung tissue in mice infected with.Inflammation-related genes were significantly upregulated at 48 h post-infection, while genes related to cell adhesion and cytoskeletal structure were downregulated.NOD-like receptor and TNF signaling pathways play a plausible role in pneumonic plague biphasic syndrome and lung injury by controlling the activation and inhibition of the NF-κB signaling pathway.