Peer-reviewed veterinary case report
Membranoproliferative kidney disease in a young male cat
By Asano, Tomoko et al.·Published in The Journal of veterinary medical science·2008·Research Institute of Biosciences, Japan·View original on PubMed →
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Original publication title: Membranoproliferative glomerulonephritis in a young cat.
- Species:
- cat
Plain-English summary
A 9-month-old male Japanese domestic cat was brought to the vet with fluid buildup in the chest and abdomen, along with signs of kidney problems like high levels of waste in the blood and low protein levels. Tests showed that the cat had a serious kidney condition called membranoproliferative glomerulonephritis, which is rare in young cats. The vet found specific changes in the kidney tissue that confirmed the diagnosis. Unfortunately, the abstract does not mention the treatment or outcome for this cat.
People also search for: cat kidney disease symptoms · why is my cat having fluid buildup · young cat kidney problems
Abstract
A 9-month-old male Japanese domestic cat showed pleural effusion, ascites, azotemia, hypoproteinemia and severe proteinuria. Histopathology of the percutaneous renal biopsy specimen revealed that all glomeruli showed intense mesangial hypercellularity with an increased mesangial matrix and thickening of the capillary walls, resulting in lobular accentuation of the glomerular tufts. Frequent duplication of the capillary walls was also observed. Immunostaining for alpha-smooth muscle actin distinctly revealed mesangial interposition. Diffuse global and linear deposition of C3 and IgG was observed mostly along the peripheral capillary loops. Electron microscopy confirmed frequent circumferential mesangial interposition and subendothelial dense-deposits in the glomerulus. The glomerular lesion was consistent with human membranoproliferative glomerulonephritis type I, and might be a rare case that developed at young age.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19122409/