Peer-reviewed veterinary case report
Ménétrier-like stomach disease causing weight loss in a dog
By Mario Pultrone et al.·Published in BMC Veterinary Research·2026·View original on Semantic Scholar →
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Original publication title: Ménétrier-like disease in a dog without glandular atrophy: expanding the morphologic spectrum
- Species:
- dog
Plain-English summary
A 6-year-old male French Bulldog was brought in for severe weight loss and a sudden lack of appetite. Tests showed that he had thickened stomach walls and abnormal growths in his stomach lining, leading to a diagnosis of Ménétrier-like disease, a rare condition that causes protein loss. The owner chose not to pursue surgery or certain medications due to cost, so the vet started treatment with steroids and other medications. Unfortunately, the dog's condition worsened over the next ten days, leading to serious neurological issues, and the difficult decision was made to euthanize him.
People also search for: dog weight loss causes · French Bulldog stomach problems · Ménétrier-like disease treatment
Abstract
Background Ménétrier’s disease is a rare protein-losing gastropathy characterized by markedly enlarged gastric folds, excessive mucus secretion, and hypoalbuminemia. Histologically, it features pronounced foveolar hyperplasia, cystic dilation of gastric glands, and loss of parietal and chief cells. Although first described in humans, a small number of comparable cases have been reported in dogs, where the condition is referred to as Ménétrier-like disease. In veterinary medicine, this disorder remains poorly defined and appears to be uncommon. Case presentation A 6-year-old intact male French Bulldog was referred for a severe progressive weight loss and acute onset anorexia. Clinical and laboratory findings were suggestive of a protein-losing enteropathy. Abdominal ultrasonography revealed marked thickening of the gastric and small intestinal walls. Gastroscopy showed severe, non-reducible hypertrophy of the gastric folds involving both the fundus and body of stomach. Endoscopic biopsies revealed marked foveolar hyperplasia and cystic glandular dilation without evidence of glandular atrophy. Ménétrier-like hypertrophic gastropathy was considered the most likely diagnosis. Given that the owner declined gastrectomy and treatment with somatostatin analogues for financial constraints, medical management with glucocorticoids and H₂-receptor antagonists was administered. After 10 days, the clinical condition progressively worsened, with the onset of new and evolving neurological deficits. The dog subsequently developed severe neurological signs, and euthanasia was ultimately elected. Histopathological examination of a full-thickness gastric sample confirmed mucosal hypertrophy characterized by branching foveolar hyperplasia and cystic dilation of the glands, again without evidence of parietal cell loss. Conclusions This case suggests that canine Ménétrier-like disease may occur even in the absence of glandular atrophy, thereby broadening the currently recognized histologic spectrum of the condition.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/0f48de4c467b4292e3986868faa1d1e12f3ee72d