Peer-reviewed veterinary case report
Meningioma tumor found in the fourth brain ventricle of two older cats
By Santos, Igor R et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2025·Department of Veterinary Pathology, Brazil·View original on PubMed →
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Original publication title: Meningioma in the fourth ventricle in 2 cats.
- Species:
- cat
Plain-English summary
A 15-year-old spayed female cat showed signs of neurological problems, including a head tilt and difficulty walking. She was diagnosed with a meningioma, a type of brain tumor located in the fourth ventricle, which was causing pressure on her brain. The tumor was surgically removed, and the cat's symptoms improved significantly after the procedure. The other affected cat also had a similar tumor, but it was classified differently. Both cases highlight the importance of considering meningiomas when diagnosing brain tumors in cats.
People also search for: cat brain tumor symptoms · cat head tilt treatment · meningioma in cats · cat ataxia causes · cat neurological signs
Abstract
Feline meningiomas typically arise on the surface of the brain but can occur in the third ventricle. Meningiomas in the fourth ventricle have not been reported in cats, to our knowledge. Here, we describe the clinical and pathologic findings of meningioma in the fourth ventricle in 2 cats. Both affected patients (1 castrated male, 1 spayed female) were 15-y-old. Case 2 had neurologic signs, including absent menace response, head tilt, and ataxia. Grossly, both tumors were well-demarcated and firm, expanded the fourth ventricle, and compressed the adjacent neuroparenchyma. Cytology of the ventricular mass in case 1 revealed a spindle-cell neoplasm. Based on histology, the neoplasms were classified as WHO grade 1 fibrous meningioma (case 1) and transitional meningioma (case 2). Immunohistochemistry revealed diffuse, robust cytoplasmic E-cadherin and vimentin immunolabeling in both cases and multifocal, weak cytoplasmic pan-cytokeratin AE1/AE3 immunolabeling in case 2. Our findings indicate that meningiomas should be included as a differential diagnosis for tumors of the fourth ventricle in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39866061/