Meta-analysis on clinical manifestation and laboratory parameters of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C).

Abstract

<h4>Objective</h4>We aimed to systematically identify clinical manifestations and lab parameters of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C).<h4>Methods</h4>We searched from Google Scholar, PubMed, and Cochrane Library with the Medical Subject Heading (MeSH) key, which includes information about clinical characteristics and severity of patient's illness. We analyzed the clinical characteristics and lab parameters of MIS-C.<h4>Results</h4>We identified a total of 44 eligible studies, including 1840 patients with COVID-19-associated MIS-C. Most common features were abdominal pain 74% (0.67,0.81), shock 72% (0.56,0.86), vomiting 69% (0.60,0.78), diarrhea 62% (0.53,0.72), rashes 60% (0.55,0.65), conjunctival infection 52% (0.44,0.60), others include myocarditis 49% (0.27,0.71), complete Kawasaki presentation 44% (0.23,0.66), respiratory distress 43% (0.16,0.73), oral mucosal changes 40% (0.31,0.49).<h4>Conclusion</h4>The results of this review show that SARS-CoV-2-associated MIS-C can present with multisystem involvement and can show an increase in inflammatory markers. MIS-C can have presentationslike Kawasaki disease, which needs high index of suspicion to diagnose MIS-C. Clinical features and lab parameters help in early diagnosis and prompt treatment.