Peer-reviewed veterinary case report
How obesity affects metabolism and heart health in cats
By Dos Santos, Thais Alessandra et al.·Published in Veterinary research communications·2025·Centro de Ciê·View original on PubMed →
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Original publication title: Metabolic and cardiovascular effects of obesity in domestic cats.
- Species:
- cat
Plain-English summary
A group of 42 neutered mixed-breed cats was studied to understand the effects of obesity on their health. The overweight and obese cats showed higher cholesterol and triglyceride levels, as well as increased blood pressure compared to normal-weight cats. These changes can lead to serious health issues, highlighting the importance of maintaining a healthy weight for cats. If your cat is overweight, it may be beneficial to discuss weight management strategies with your veterinarian to help improve their overall health.
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Abstract
Obesity in cats has become increasingly prevalent in clinical practice and is associated with several comorbidities and reduced longevity. However, data on metabolic alterations in overweight or obese cats remain limited. This study aimed to evaluate hematological, lipid profile, oxidative metabolism, and cardiovascular parameters in overweight and obese cats. A total of 42 neutered mixed-breed cats were included and divided into three groups (n = 14): control group, overweight group, and obese group. Animals were selected based on medical history, physical examination, complete blood count, FIV/FeLV serology, and biochemical profile; individuals with comorbidities were excluded. Evaluations included complete blood count, lipid profile, malondialdehyde (MDA), reduced glutathione (GSH), erythrocyte osmotic fragility, electrocardiogram, and systemic blood pressure. Overweight cats showed significantly elevated cholesterol levels (179.93 ± 37.41 mg/dL; p = 0.003). Obese cats showed lymphopenia (1175 cells/µL; 871-2662), increased cholesterol (181.92 ± 27.78 mg/dL; p = 0.003), triglycerides (117 mg/dL; 80-211; p = 0.002), very low-density lipoprotein (VLDL) (30.7 ± 20 mg/dL; p = 0.001), and systolic blood pressure (160.3 ± 20.56 mmHg; p < 0.001) compared to the control group. In conclusion, feline obesity induces significant alterations in hematological, lipid, and cardiovascular parameters, indicating a relevant systemic impact.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41085900/