Peer-reviewed veterinary case report
Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma.
- Journal:
- Research in veterinary science
- Year:
- 2011
- Authors:
- Mees, G et al.
- Affiliation:
- Department of Nuclear Medicine and Molecular Imaging · Netherlands
- Species:
- dog
Abstract
Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (R=0.607; p=0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21316722/