Peer-reviewed veterinary case report
Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia.
- Journal:
- The Journal of small animal practice
- Year:
- 2007
- Authors:
- Cave, T A et al.
- Affiliation:
- Cave Referrals · United Kingdom
- Species:
- dog
Abstract
A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17543017/