Peer-reviewed veterinary case report
Dog with skin necrosis linked to pancreatic cancer and hormone
By Cave, T A et al.·Published in The Journal of small animal practice·2007·Cave Referrals, United Kingdom·View original on PubMed →
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Original publication title: Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia.
- Species:
- dog
Plain-English summary
A 10-year-old male mixed-breed dog was brought in with severe skin problems, known as metabolic epidermal necrosis, which were linked to pancreatic cancer. The dog's blood tests showed low protein levels and abnormal hormone levels, indicating that the cancer was affecting its metabolism. Despite attempts to provide nutritional support, the treatments did not help, and the cancer had spread to nearby lymph nodes. Sadly, the dog was euthanized due to the severity of its condition.
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Abstract
A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17543017/