Peer-reviewed veterinary case report
Metabolic differences in diabetic cats in remission and relapse risk
By Gottlieb, Susan et al.·Published in Frontiers in veterinary science·2020·The Cat Clinic, Australia·View original on PubMed →
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Original publication title: Metabolic Profiling of Diabetic Cats in Remission.
- Species:
- cat
Plain-English summary
A group of diabetic cats that were in remission were monitored to see if they would relapse into diabetes. Most of these cats still had issues with how their bodies handled sugar, even though they seemed healthy. Over the course of the study, five of the cats did relapse, but researchers couldn't find any specific markers in their blood that could predict this relapse. This suggests that while some cats can go into remission, they may still have underlying metabolic problems that could lead to a return of diabetes.
People also search for: diabetic cat remission symptoms · why did my cat relapse diabetes · managing diabetes in cats · blood sugar levels in diabetic cats
Abstract
The majority of diabetic cats in remission have abnormal glucose tolerance, and approximately one third relapse within 1 year. Greater understanding of the metabolic characteristics of diabetic cats in remission, and predictors of relapse is required to effectively monitor and manage these cats.To identify and compare differences in plasma metabolites between diabetic cats in remission and healthy control cats using a metabolomics approach. Secondly, to assess whether identified metabolites are predictors of diabetic relapse.Twenty cats in diabetic remission for a median of 101 days, and 22 healthy matched control cats.Cats were admitted to a clinic, and casual blood glucose was recorded. After a 24 h fast, blood glucose concentration was measured, then a blood sample was taken for metabolomic (GCMS and LCMS) analyses. Three hours later, a simplified intravenous glucose tolerance test (1 g glucose/kg) was performed. Cats were monitored for diabetes relapse for at least 9 months (270 days) after baseline testing.Most cats in remission continued to display impaired glucose tolerance. Concentrations of 16 identified metabolites differed (≤ 0.05) between remission and control cats: 10 amino acids and stearic acid (all lower in remission cats), and glucose, glycine, xylitol, urea and carnitine (all higher in remission cats). Moderately close correlations were found between these 16 metabolites and variables assessing glycaemic responses (most || = 0.31 to 0.69). Five cats in remission relapsed during the study period. No metabolite was identified as a predictor of relapse.This study shows that cats in diabetic remission have abnormal metabolism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32500084/