Peer-reviewed veterinary case report
Metabolites of non-aureus staphylococci affect the ability of Staphylococcus aureus to adhere to and internalize into bovine mammary epithelial cells.
- Journal:
- Veterinary research
- Year:
- 2023
- Authors:
- Toledo-Silva, Bruno et al.
- Affiliation:
- Department of Internal Medicine
Abstract
This study investigated whether cell-free supernatants (SN) from four bovine non-aureus staphylococcal (NAS) isolates prevent Staphylococcus aureus adhesion to and internalization into bovine mammary epithelial cells (MAC-T cells) and if so, to determine whether such effects were potentially associated with the S. aureus accessory gene regulator (agr) system. Overall, we demonstrated that all SN obtained from the NAS isolates promoted adhesion of a S. aureus agrstrain to, yet reduced the internalization into MAC-T cells, while similar effects were not observed for its agrmutant strain. Our findings provide novel anti-virulence strategies for treating and controlling bovine S. aureus mastitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37884947/