Peer-reviewed veterinary case report
Metastasis-promoting immunity: when T cells turn to the dark side.
- Journal:
- Cancer cell
- Year:
- 2009
- Authors:
- Pardoll, Drew
- Affiliation:
- Johns Hopkins University School of Medicine · United States
Abstract
While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19647215/