Peer-reviewed veterinary case report
Metastatic eye cancer in a 15-year-old female Labrador Retriever
By Zarfoss, M K & Dubielzig, R R·Published in Veterinary pathology·2007·Department of Pathobiological Sciences, United States·View original on PubMed →
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Original publication title: Metastatic iridociliary adenocarcinoma in a labrador retriever.
- Species:
- dog
Plain-English summary
A 15-year-old female spayed Labrador Retriever had her left eye removed due to a tumor, which was later found to be a type of cancer called metastatic iridociliary adenocarcinoma. After the eye was taken out, further tests revealed that the cancer had spread to the surrounding area and even to the lungs. Unfortunately, this type of cancer is quite serious, and the dog did not survive long after the diagnosis. This case highlights the importance of monitoring older dogs for unusual growths or symptoms, as early detection can be crucial.
People also search for: dog eye cancer symptoms · Labrador Retriever cancer treatment · metastatic cancer in dogs
Abstract
An enucleated left eye from a 15-year-old female spayed Labrador Retriever was received by the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) for histopathologic evaluation. Routine histologic preparation included staining with hematoxylin and eosin, and with alcian blue periodic acid-Schiff (PAS). At necropsy 9 months later, all grossly abnormal tissues (ipsilateral orbit and lung) were submitted to the COPLOW for histopathologic evaluation. Histopathologic evaluation of the globe revealed extensive invasion of the uvea and sclera by a pleomorphic cell population that formed disorganized cords and exhibited PAS-positive basement membrane material. Necropsy revealed a morphologically similar tumor in the ipsilateral orbit and lung. On immunohistochemical examination, the intraocular tumor stained diffusely immunopositive for vimentin, S-100, and neuron-specific enolase and multifocally, sparsely immunopositive for cytokeratin AE1/AE3. The orbital and thoracic tumors stained positively for vimentin but negatively for cytokeratin AE1/AE3. There are few reports of canine metastatic iridociliary adenocarcinoma in the literature; this is the first with immunohistochemical analysis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17846239/