Peer-reviewed veterinary case report
Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2017
- Authors:
- Dutta, Noton K et al.
- Affiliation:
- Department of Medicine · United States
- Species:
- rodent
Abstract
Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28559262/