Peer-reviewed veterinary case report
Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2010
- Authors:
- Shook, Brian C et al.
- Affiliation:
- Johnson & Johnson Pharmaceutical Research and Development · United States
Abstract
A novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20347304/