Peer-reviewed veterinary case report
Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Shrestha, Suja et al.
- Affiliation:
- Department of Chemistry and Institute of Molecular Cell Biology · South Korea
Abstract
Methylenedisalicylic acid derivatives were synthesized and their inhibitory activities against protein tyrosine phosphatases (PTPases) examined. Two of the compounds, 8 and 9, showed K(i) values of 9.4 and 6.3microM against PTP1B, 4- and 7-fold lower values compared to those against TC-PTP. They were reversible and slow-binding inhibitors against PTP1B. When compound 8 was fed to a mouse model, the weight gain and adipocyte fat storage induced by a high-fat-diet were significantly suppressed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17368023/