Peer-reviewed veterinary case report
Mginhibits infection of spring viraemia of carp virus (SVCV) by enhancing IRF3 expression.
- Journal:
- Developmental and comparative immunology
- Year:
- 2025
- Authors:
- Xu, Na et al.
- Affiliation:
- Institute of Hydrobiology · China
Abstract
Magnesium ions (Mg), essential divalent cations, play a pivotal role in orchestrating a myriad of physiological and biochemical processes. However, the intricate relationship between Mghomeostasis and antiviral immunity in fish remains largely unexplored. In this study, we found that Mgenhances the interferon (IFN) response by increasing the expression of IFN regulatory factor 3 (IRF3) to inhibit spring viraemia of carp virus (SVCV) infection. In vivo studies showed Mgincreases the survival rate of SVCV-infected zebrafish while reducing viral transcription and load in liver tissues. Consistent results were obtained in vitro. Further investigations revealed that Mgcan enhance the endogenous expression of IRF3. Additionally, upon SVCV infection, Mgrescues the virus-induced degradation of IRF3. These findings underscore the pivotal role of Mgin the antiviral response of lower vertebrates, presenting a promising avenue for addressing fish viral diseases.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40555309/