Peer-reviewed veterinary case report
Genetic risk linked to chronic eye disease in German Shepherd dogs
By Jokinen, Päivi et al.·Published in Veterinary immunology and immunopathology·2011·Department of Veterinary Biosciences·View original on PubMed →
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Original publication title: MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
- Species:
- dog
Plain-English summary
A group of German Shepherd dogs with chronic superficial keratitis (CSK), an eye condition that can lead to blindness, was studied to understand its causes. Symptoms of CSK include progressive changes in the cornea, such as blood vessel growth and pigmentation. The research found that certain genetic markers were linked to a higher risk of developing this condition, especially in female dogs. Identifying these genetic factors can help veterinarians understand which dogs may be more susceptible to CSK and guide treatment options.
People also search for: German Shepherd eye problems · chronic superficial keratitis treatment · dog corneal disease symptoms
Abstract
Canine chronic superficial keratitis (CSK) is an inflammatory ocular disease of an autoimmune origin leading to blindness if untreated. The main symptoms of CSK are progressive, bilateral vascularisation, fibrous tissue formation and pigmentation of the anterior corneal stroma. Although CSK is found in many breeds it is most prevalent in German Shepherd dogs (GSDs). Since Major Histocompatibility Complex (MHC) class II is associated with several autoimmune diseases in dogs we investigated the possible role of DLA-DRB1, -DQA1 and -DQB1 in GSDs affected with CSK. Our study population included 25 healthy controls and 30 CSK dogs. Most of the affected dogs were females suggesting a female predisposition. We identified 11 unevenly distributed haplotypes of which DLA-DRB1*01501/DQA1*00601/DQB1*00301 was significantly associated with the CSK dogs (OR=2.67, CI=1.17-6.44, p=0.02). We also found that overall homozygosity of MHC class II increases risk for CSK (OR=4.37, CI=1.27-18.46, p=0.02) and homozygosity of the risk haplotype by over eight-fold (OR=8.5, 95% CI=1.4-224, p=0.017). This study identifies a MHC class II risk haplotype for CSK in GSD and further supports the autoimmune origin of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21144596/