Peer-reviewed veterinary case report
Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Jacobson, Amanda C et al.
- Affiliation:
- Department of Pathology · United States
- Species:
- rodent
Abstract
CD21/35(-/-) mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17283093/