Peer-reviewed veterinary case report
Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus.
- Journal:
- Journal of medicinal chemistry
- Year:
- 2017
- Authors:
- Wang, Fenghua et al.
- Affiliation:
- School of Life Sciences · China
Abstract
Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (M) plays an essential role in viral replication. We solved the structure of PEDV Mcomplexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing atomic level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV M. These compounds have potential as future therapeutics to combat PEDV infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28287727/