Peer-reviewed veterinary case report
Microbiota and reproducibility of rodent models.
- Journal:
- Lab animal
- Year:
- 2017
- Authors:
- Franklin, Craig L & Ericsson, Aaron C
- Affiliation:
- Department of Veterinary Pathobiology at the University of Missouri in Columbia
Abstract
The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28328896/