Peer-reviewed veterinary case report
Pregnancy termination in cats using aglepristone at mid-gestation
By Georgiev, Plamen & Wehrend, Axel·Published in Theriogenology·2006·Department of Obstetrics·View original on PubMed →
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Original publication title: Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens.
- Species:
- cat
Plain-English summary
A group of pregnant cats (queens) received a medication called aglepristone to terminate their pregnancies about 25 days after mating. Out of 23 treated queens, 20 successfully aborted their pregnancies, with most starting to show signs of discharge within about five days after the first injection. The treatment was effective in 87% of the cases, while the control group of untreated queens all gave birth to healthy kittens after a normal pregnancy. The only side effect noted was mild itching at the injection site in one cat.
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Abstract
The efficacy of aglepristone, a progesterone receptor antagonist, to induce abortion on days 25 and 26 after first mating was investigated in queens. The cats were divided into two groups: aglepristone (10 mg/kg, subcutaneously) was injected twice, 24 h apart, on days 25 and 26 after first mating, into group I queens (n = 23). Group II queens (n = 6) were not treated and served as controls. Termination of pregnancy and expulsion of the fetuses were successful in 20 (87%) queens in group I. The mean interval between the first administration of aglepristone and the beginning of vaginal discharge was 5+/-1 days (range 4-7 days) and the mean duration of abortion, defined as time span from first occurrence of vaginal discharge to expulsion of all fetuses observed by ultrasonography was 1 day in nine cats, 2 days in five cats and in five cats, less than 1 day. Treatment failed in three queens. In one queen treatment resulted in birth (66 days after mating) of two vital kittens. In another case, three macerated fetuses were found intrauterine without vaginal discharge. In one cat, two fetuses were expulsed and two remained intrauterine and were born 66 days after last mating. All group II queens gave birth to vital kittens after a normal pregnancy length. The mean serum P4 concentrations were similar in treated and control animals. The results indicate that aglepristone treatment at day 25 of pregnancy could induce abortion in 87% of the treated queens. Itching at the site of injection right after injection was the only side effect noticed and only in one queen.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16198402/