Peer-reviewed veterinary case report
Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA.
- Journal:
- Biochemical and biophysical research communications
- Year:
- 2006
- Authors:
- Yamamoto, Hideki et al.
- Affiliation:
- Department of Biochemistry · Japan
Abstract
Intraperitoneally administered chondroitin sulfate E inhibited the development of antibody-induced arthritis, a model of rheumatoid arthritis, while chondroitin 4-sulfate showed no effects. Chondroitin sulfate E inhibited in vitro differentiation of osteoclasts, which play key roles in the etiology of rheumatoid arthritis. One of the targets of chondroitin sulfate E is midkine, a heparin-binding growth factor or cytokine. Indeed, a chimeric-type siRNA for midkine inhibited the development of antibody-induced arthritis and adhesion of the omentum to the injured abdominal wall. These results indicate the significance of midkine as a molecular target to treat or prevent rheumatoid arthritis and adhesion after surgery, and the utility of chondroitin sulfate E to inhibit midkine in vivo.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17094944/